Once the polar ice caps melt, tidal waves, floods, and massive weather pattern disruptions around the globe will result; a magnetic pole shift will cause the Earth's crust will spin on it's molten core, wiping the planet clean of most life.
...just in time for the often maligned and misunderstood mole people to regain their former status as ruling elite. Just so I can tell you I said it here first, I'm planning to reincarnate as a purple radioactive crack weasel.
Er, or the shit is just going to get hot around here, y0.