Gates Gives $450 Million Dollars To Oddball Research
Read the direction of where some of this research is going. Why no theories behind mosquitos building immunity to insecticides and AIDS? Get on it man, I may have had an epiphinay with this one.

by Stump 1610 Reads
on Thu Dec 08 2005 Add to your ClipSwarm
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PilferedProdginyFri Dec 09
 
This is the coolest thing I've read about Gates.

I wonder what he'll do with next week's profits.
 
 
StumpSat Dec 10
 
What really intrigued me was the mention of mosquitos and their ability to mutate to avoid insecticide deaths. Has anyone ever done a comparative analysis of AIDS and the mosquito's genome? Why the belief it was mutated directly from monkey contact, is it possible it was originally transmitted by mosquito?
 
 
pchimpSat Dec 10
 
A potential link between mosquitos and HIV spread was fairly heavily investigated when AIDS research was trying to catch up to the new epidemic. Transmission by mosquito is theoretically possible, but not practically so.

In order to transmit the virus, a mosquito would have to drink from an infected individual and uptake a rather large number of virus particles (already unlikely if you consider the concentration of HIV and the volume of blood a mosquito ingests). Next, the virus must survive the digestive tract long enough to make it into the mosquito's blood -- HIV (like most viruses) doesn't live long in the digestive acids. Then, those few (theoretical) particles need to find their way into the saliva of the mosquito when it bites it's next victim. This route is basically impossible.

Another route is squashing an HIV-laden mosquito while it's biting a non-infected individual, presumedly allowing the mosquito juice to mingle with the tiny open puncture bite wound. Doing the calculation noted above, though, it's easy to show that even if the mosquito initially drank from an individual at the peak of HIV expression in the blood, there was no digestion of the virus, and all of the mosquito's payload was mixed with the target; there would still not be enough particles to spread the infection.

It's oft-noted when the topic comes up that there has never been a confirmed case of HIV spread by mosquito, and also worth noting that AIDS spread did not appear to track malarial or other known blood-borne pathogen patterns.
 
 
StumpSat Dec 10
 
Thanks for the answer Pchimp!
 
 


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